<scp>Solute carrier family 35 member D3</scp> promotes colorectal cancer progression through <scp>AMPK</scp> signaling pathway

This article is aim to investigate the functional role and potential regulatory mechanisms of solute carrier family 35 member D3 (SLC35D3) in colorectal cancer. Beyond analyzing databases, western blot was used detect verify expression SLC35D3. Cell proliferation invasion or migration ability were detected by CCK-8, EdU, Transwell assays. Animal experiments conducted if biological function SLC35D3 vivo consistent with that vitro. SLC pathway enrichment analysis, relationship between metabolic AMPK explored using co-immunoprecipitation blot. highly expressed cancer (CRC) tissue. The overexpression down regulation has been shown promote inhibit functions cancer, similar experimental results can be verified experiments. Based on high correlation pathways, we chose metabolic-related as subject our research. Co-immunoprecipitation protein analysis demonstrated may bind molecules regulate cells. above facts, promotes progression through regulating signaling pathway.